
Data dictionary for grid_full_mean2020-11-29.csv. This is the raw simulation output from simulation-batch.R optimization for dual bnab combinations.

This dataset is wide across all simulation outcomes, each row is the result of one simulation set over 1000 simulated virus (total_virus_sims). The settings for each bnab are stored in that row, `_1` denotes bnab1 and `_2` denotes bnab2. 

Outcome notation:

- Interaction model: min (minimum), max (maximum), BH (Bliss-Hill), add (additivity)
- PKPD outcome: ID50 (titer), ID50 (log10 titer), neut (neutralization, proportion), iip (instantaneous inhibitory potential, -log10(1-neut))
- PKPD summary function at time point: mean (mean over viruses), coverage (prop. of viruses < outcome threshold, see below for threshold defs)
- PKPD time summary: auc (over total time / final time), trough (value at final time point, day 84)


|Variable names                       |Description                                           |
|:------------------------------------|:-----------------------------------------------------|
|hl_1                                 | Half-life (days) bnab 1                              |
|hl_2                                 | Half-life (days) bnab 2                              |
|omega_1                              | Proportion sensitive viruses, bnab1                  |
|omega_2                              | Proportion sensitive viruses, bnab2                  |
|muIC50_1                             | Mean sensitive virus log10 IC50 (ug/mL), bnab1       |  
|muIC50_2                             | Mean sensitive virus log10 IC50 (ug/mL), bnab2       |
|sigIC50_1                            | Std.dev. sensitive virus log10 IC50 (ug/mL), bnab1   |
|sigIC50_2                            | Std.dev. sensitive virus log10 IC50 (ug/mL), bnab2   |
|c0                                   | Total concentration dose (ug/mL)                     |
|virus_seed                           | Randomization seed used for that simulation row      |
|total_virus_sims                     | Total simulation (sampled) viruses in sim            |
|conc_1_auc                           | AUC concentration, bnab 1                            |
|conc_2_auc                           | AUC concentration, bnab 2                            |
|conc_1_trough                        | trough concentration, bnab 1                         |
|conc_2_trough                        | trough concentration, bnab 2                         |
|ratio                                | Dose ratio for bnab 1 (dose_1 = c0 * ratio)          |
|sim                                  | parallelization ID (can be ignored)                  |
|min_ID50_mean_auc                    | mean titer auc (see above for notation definitions)  |
|max_ID50_mean_auc                    |                                                      |
|add_ID50_mean_auc                    |                                                      |
|BH_ID50_mean_auc                     |                                                      |
|min_ID50log10_mean_auc               | mean log10 titer auc                                 |
|max_ID50log10_mean_auc               |                                                      |
|add_ID50log10_mean_auc               |                                                      |
|BH_ID50log10_mean_auc                |                                                      |
|BH_neut_mean_auc                     | mean neut auc                                        |
|additivity_neut_mean_auc             |                                                      |
|maxNeut_neut_mean_auc                |                                                      |
|minNeut_neut_mean_auc                |                                                      |
|BH_iip_mean_auc                      | mean iip auc                                         |
|additivity_iip_mean_auc              |                                                      |
|maxNeut_iip_mean_auc                 |                                                      |
|minNeut_iip_mean_auc                 |                                                      |
|min_ID50_coverage1_mean_auc          | titer coverage (ID50 > 1)                            |
|max_ID50_coverage1_mean_auc          |                                                      |
|add_ID50_coverage1_mean_auc          |                                                      |
|BH_ID50_coverage1_mean_auc           |                                                      |
|min_ID50_coverage10_mean_auc         | prop. viruses (ID50 > 10)                            |
|max_ID50_coverage10_mean_auc         |                                                      |
|add_ID50_coverage10_mean_auc         |                                                      |
|BH_ID50_coverage10_mean_auc          |                                                      |
|min_ID50_coverage100_mean_auc        | prop. viruses (ID50 > 100)                           |
|max_ID50_coverage100_mean_auc        |                                                      |
|add_ID50_coverage100_mean_auc        |                                                      |
|BH_ID50_coverage100_mean_auc         |                                                      |
|min_ID50_coverage1000_mean_auc       | prop. viruses (ID50 > 1000)                          |
|max_ID50_coverage1000_mean_auc       |                                                      |
|add_ID50_coverage1000_mean_auc       |                                                      |
|BH_ID50_coverage1000_mean_auc        |                                                      |
|min_ID50_coverage1e4_mean_auc        | prop. viruses (ID50 > 10000)                         |
|max_ID50_coverage1e4_mean_auc        |                                                      |
|add_ID50_coverage1e4_mean_auc        |                                                      |
|BH_ID50_coverage1e4_mean_auc         |                                                      |
|BH_iip_coverage1_mean_auc            | prop. viruses (IIP > 1)                              |
|additivity_iip_coverage1_mean_auc    |                                                      |
|maxNeut_iip_coverage1_mean_auc       |                                                      |
|minNeut_iip_coverage1_mean_auc       |                                                      |
|BH_iip_coverage2_mean_auc            | prop. viruses (IIP > 2)                              |
|additivity_iip_coverage2_mean_auc    |                                                      |
|maxNeut_iip_coverage2_mean_auc       |                                                      |
|minNeut_iip_coverage2_mean_auc       |                                                      |
|BH_iip_coverage3_mean_auc            | prop. viruses (IIP > 3)                              |
|additivity_iip_coverage3_mean_auc    |                                                      |
|maxNeut_iip_coverage3_mean_auc       |                                                      |
|minNeut_iip_coverage3_mean_auc       |                                                      |
|BH_iip_coverage4_mean_auc            | prop. viruses (IIP > 4)                              |
|additivity_iip_coverage4_mean_auc    |                                                      |
|maxNeut_iip_coverage4_mean_auc       |                                                      |
|minNeut_iip_coverage4_mean_auc       |                                                      |
|min_ID50_mean_trough                 | Same as above, but trough rather than auc            |
|max_ID50_mean_trough                 |                                                      |
|add_ID50_mean_trough                 |                                                      |
|BH_ID50_mean_trough                  |                                                      |
|min_ID50log10_mean_trough            |                                                      |
|max_ID50log10_mean_trough            |                                                      |
|add_ID50log10_mean_trough            |                                                      |
|BH_ID50log10_mean_trough             |                                                      |
|BH_neut_mean_trough                  |                                                      |
|additivity_neut_mean_trough          |                                                      |
|maxNeut_neut_mean_trough             |                                                      |
|minNeut_neut_mean_trough             |                                                      |
|BH_iip_mean_trough                   |                                                      |
|additivity_iip_mean_trough           |                                                      |
|maxNeut_iip_mean_trough              |                                                      |
|minNeut_iip_mean_trough              |                                                      |
|min_ID50_coverage1_mean_trough       |                                                      |
|max_ID50_coverage1_mean_trough       |                                                      |
|add_ID50_coverage1_mean_trough       |                                                      |
|BH_ID50_coverage1_mean_trough        |                                                      |
|min_ID50_coverage10_mean_trough      |                                                      |
|max_ID50_coverage10_mean_trough      |                                                      |
|add_ID50_coverage10_mean_trough      |                                                      |
|BH_ID50_coverage10_mean_trough       |                                                      |
|min_ID50_coverage100_mean_trough     |                                                      |
|max_ID50_coverage100_mean_trough     |                                                      |
|add_ID50_coverage100_mean_trough     |                                                      |
|BH_ID50_coverage100_mean_trough      |                                                      |
|min_ID50_coverage1000_mean_trough    |                                                      |
|max_ID50_coverage1000_mean_trough    |                                                      |
|add_ID50_coverage1000_mean_trough    |                                                      |
|BH_ID50_coverage1000_mean_trough     |                                                      |
|min_ID50_coverage1e4_mean_trough     |                                                      |
|max_ID50_coverage1e4_mean_trough     |                                                      |
|add_ID50_coverage1e4_mean_trough     |                                                      |
|BH_ID50_coverage1e4_mean_trough      |                                                      |
|BH_iip_coverage1_mean_trough         |                                                      |
|additivity_iip_coverage1_mean_trough |                                                      |
|maxNeut_iip_coverage1_mean_trough    |                                                      |
|minNeut_iip_coverage1_mean_trough    |                                                      |
|BH_iip_coverage2_mean_trough         |                                                      |
|additivity_iip_coverage2_mean_trough |                                                      |
|maxNeut_iip_coverage2_mean_trough    |                                                      |
|minNeut_iip_coverage2_mean_trough    |                                                      |
|BH_iip_coverage3_mean_trough         |                                                      |
|additivity_iip_coverage3_mean_trough |                                                      |
|maxNeut_iip_coverage3_mean_trough    |                                                      |
|minNeut_iip_coverage3_mean_trough    |                                                      |
|BH_iip_coverage4_mean_trough         |                                                      |
|additivity_iip_coverage4_mean_trough |                                                      |
|maxNeut_iip_coverage4_mean_trough    |                                                      |
|minNeut_iip_coverage4_mean_trough    |                                                      |